Happy Darwin Day (2017)

My series of blog posts about the refutation of theistic evolution by George Church led him to contact me via email. He asked why he would get credit for or against the refutations He claimed he was trained in quantum physics. He claimed that he has authored peer reviewed papers on protein folding, biodiversity, supercoiling, […]

Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for […]

Energy-dependent alternative splicings 1996 – 2016 (2)

See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession […]

Explorers who do not know what is known (2)

See: Explorers who do not know what is known See also: Energy-dependent polycombic ecological adaptation Now see: The B/Z reaction, and the problem with peer review December 9. 2016 by John Leonard … oscillating chemical reactions predictable by mathematical formula are partially responsible for organizing cells to form organs, bone, and tissue. Alan Turing didn’t […]

Light, behavior and autophagy, a gender-specific risk factor

Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery […]

RNA-mediated "repurposing" is autophagy

Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning “self-devouring”[1] and κύτος kýtos, meaning “hollow”[2]) is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.[3] RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled RNA-mediated repurposing in microbes and adaptations in primate brains Selective reporting of inferences: examples of pseudoscience Autophagy Pioneer […]

Epigenetics and autophagy vs mutations and evolution (8)

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides. Epub 2014/12/30 Abstract except:   This optimized RNA isolation procedure thus provides a means to more rigorously explore the biology of ncRNA species in mycobacteria. Reported 2016/11/11 […]

Epigenetics and autophagy vs mutations and evolution (7)

RNA interference (RNAi) fails to protect all cell types from virus-driven energy theft. The effect on some cell types cannot be controlled. That’s because nutrient energy-dependent endogenosymbiosis and the pheromones-controlled physiology of reproduction protect the organized genomes of species from microbes to humans. Billions of waster dollars have been spent with no end to the […]

Hecatombic evolution via oncocers and oncohistones

Mutation-driven evolution is being replaced by a theory of hecatombic evolution that links oncocers and oncohistones to increasing organismal complexity via autophosphorylation and autophagy or something else as yet to be invented in the context of the new ridiculous theory. See for comparison: Polycomb enables primitive endoderm lineage priming in embryonic stem cells Abstract excerpt: […]