The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked to the prevention of the virus-driven degradation of messenger RNA […]
Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of […]
Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That […]
Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to […]
The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear […]
Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular […]
National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past […]
Autophagy is activated by virus-driven energy theft. Click on the term “Autophagy” That fact is clear in the diagram of systems complexity and in my model. See for contrast: Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors A key question in virology, that is potentially answerable using paleovirological analyses, is what […]
Energy as information and constrained endogenous RNA interference poster presentation February 15, 2017 KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer February 23, 2017 These studies demonstrate that serial genetic changes at the Kras/KRAS locus are frequent in cancer and modulate competitive fitness and MEK dependency. Reported as: Genetic ‘balance’ may […]
I added a video track to the audio track that already accompanies this presentation. See also: High-Power Actuation from Molecular Photoswitches in Enantiomerically Paired Soft Springs Reported as: Molecular switch drives powerful movement by opposing twisting helices Inspired by the evolutionary strategies that support the movement of plants, the team headed by Stephen P. Fletcher […]
