Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for […]

Energy-dependent alternative splicings 1996 – 2016 (2)

See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession […]

Energy-dependent alternative splicings 1996 – 2016

Highlights: 1) Alternative splicings of messenger RNA link the sun’s anti-entropic virucidal energy as information to DNA repair. 2) DNA repair links fixation of amino acid substitutions in supercoiled DNA to healthy longevity. 3) Supercoiled DNA protects all organized genomes from virus-driven energy theft and genomic entropy. 4) Genomic entropy is less likely to occur […]

The futility of The Battlefield FB group

Apparently, Paul Hartley blocked me from further discussion of his OP about dinosaurs and gladiators before I could ask if he thought “The Battlefield” is a “false flag” group. Does anyone else think that?   If so, do you think it can survive publication of experimental evidence that links responsive supramolecular systems to stepwise changes […]

De novo gene creation: Ignoring the experimental evidence

Regularly Whiffing Essential Oils Can Retrain Lost Sense of Smell It’s not entirely clear how olfactory training works on a neurological level. Olfactory training links the experience-dependent de novo creation of G protein-coupled receptors to supercoiled DNA. Conserved molecular mechanisms link food odors and pheromones from the innate immune system to the physiology of reproduction. […]

Epigenetics and autophagy vs mutations and evolution (7)

RNA interference (RNAi) fails to protect all cell types from virus-driven energy theft. The effect on some cell types cannot be controlled. That’s because nutrient energy-dependent endogenosymbiosis and the pheromones-controlled physiology of reproduction protect the organized genomes of species from microbes to humans. Billions of waster dollars have been spent with no end to the […]

RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled

 Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Excerpt: The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2). Reported as: Evolutionary Rewiring Strong selective pressure can lead to […]

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