GnRH Archives - Autophagy

Nature vs Science and Autophagy.pro

Dec 15, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variationsautophagy, biophysically constrained biodiversity, Calcium, Chloride, epistasis, feedback loops, fertility, Glucose, GnRH, gonadotropin-releasing hormone, healthy longevity, Hematocrit, Hemoglobin, hydrogen-atom transfer in DNA base pairs in solution, innate immune system, insects, intracellular signaling, intranuclear interactions, Lactic Acid, LH secretion, light, mammals, microbes, microRNA/messenger RNA balance, molecular epigenetics, nematodes, network of hydrogen bonds, nutritional epigenetics, pCO2, pH, pheromone-controlled, pO2, Potassium, potential of hydrogen, replication of viruses, selection for phenotype, single amino acid substitution, Sodium, stochastic gene expression, Virus-driven energy theft

Conclusion: The anti-entropic virucidal energy of sunlight links food energy directly from the innate immune system to all morphological and behavioral diversity. It all about energy. It’s all about the creation of enzymes. It’s all about the base pairs. Until the day that I launched Autophagy.pro, I had only one or two Facebook posts that […]

Energy-dependent structure and function: Until death (3)

Oct 11, 2017James KohlAutophagy, RNA Directedachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That […]

Energy-dependent structure and function: Until death (2)

Oct 11, 2017James KohlAutophagy, RNA Directedachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to […]

Energy-dependent structure and function: Until death (1)

Oct 11, 2017James KohlAutophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variationsachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear […]

Can protein folding chemistry be understood by theorists?

Aug 3, 2017James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsatoms to ecosystems, ATP dependent, autophagy, Bruce McEwen, Cancer Mutations, chirality, chromosomal rearrangements, cological niche construction, ctenophore, de novo Creation, Denise Chen, DNA Folding, DNA structure, Donald Pfaff, ecological adaptations, energy-dependent, evolution of intelligence, GnRH, Gut viruses, hematopoiesis, isoforms, Martha McClintock, microRNA / messenger RNA balance, Moroz, neo-Darwinian evolution, neurogenic niche construction, niche construction, non-inherited genetic change, physiology of pheromone-controlled reproduction, quantum physics, Quantum Souls, RNA SYNTHESIS, RNA-mediated, Robert L. Moss, secondary loss of neurons and synapses, social niche construction, socio-cognitive niche construction, Textbook Model, tumor viruses, uncontrolled cell growth, virus-driven degradation of messenger RNA, Wen Zhou

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular […]

Energy-dependent physical and biophysical constraints (9)

Jul 28, 2017James KohlAdaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations, What's in the News3D chromatin structure, autophagy, base pairs, chirality, de novo Creation, degradation of messenger RNA, DNA organization, enzymes, G-protein-coupled receptors, GnRH, gonadotropin-releasing hormone, hormones, interphase, microRNAs, mitosis, mitotic cells, model, negative supercoiling, organized genomes, physiology. pheromone-controlled reproduction, Receptors, RNA-mediated amino acid substitutions, Scent of Eros, single nucleotide polymorphisms, supercoiled DNA, Virus-driven energy theft

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin […]