food odors Archives - Autophagy

Energy-dependent structure and function: Until death (3)

Oct 11, 2017James KohlAutophagy, RNA Directedachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That […]

Energy-dependent structure and function: Until death (2)

Oct 11, 2017James KohlAutophagy, RNA Directedachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to […]

Energy-dependent structure and function: Until death (1)

Oct 11, 2017James KohlAutophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variationsachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear […]

Draining the academic swamp of parasites

May 3, 2017James KohlAdaptations, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, Variationsapoptosis, autophagy, biodiversity, biophysically constrained, blood sugar, brain cancer, chromosomal inheritance, Commensal bacteria, Conflict of Interest, Ecological model, energy as information, energy-dependent, energy-dependent RNA-mediated DNA repair, essential amino acids, feedback loops, food odors, hydrogen-atom transfer in DNA base pairs in solution, Ian Hodder, microRNA, nutrient energy-dependent microRNAs, pathology, pheromones, Resource availability, RNA-mediated, species abundance, supercoiled DNA, Suzan Mazur, Top-down causation, Transcription, virus-driven degradation of messenger RNA

National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past […]

Functionally interdependent editing and methylation

Apr 4, 2017James KohlAdaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsanticodon loop, autophagy, Billion Dollar Baby, chirality, de novo Creation, deaminase ADAT2/3, editing, endogenous viral elements, energy-dependent codon optimality, feedback loops, flanking sequences, food odors, functionally interdependent, guardian RNAs, human codon-optimized, hydrogen-atom transfer in DNA base pairs in solution, irus-driven energy theft, light, luteinizing hormone, m3C methyltransferase, Methylation, microRNA, microRNAs, mRNA stability, mutagenic enzyme, mutagenicity, natural selection for energy-dependent codon optimality, neurogenesis, OXIDATIVE PHOSPHORYLATION, pheromones, physiology of reproduction, protein conjugation, RNA interference, RNA-directed DNA methylation, RNAi, supercoiled DNA, Supramolecular Assembly, synthesis of RNA, Virus-driven energy theft

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C […]

Energy-dependent oscillating gene networks organize life

Dec 26, 2016James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsalternative RNA splicings, alternative splicing techniques of pre-mRNA, autophagy, bio-functional information, biodiversity, cellular intelligence, DNA repair, energy as information, energy is information, epigenetic influences, experimental evidence, food odors, G-protein-coupled receptors, Human Pheromones, immune system, Jon Lieff, Mazur, mutation-initiated, natural selection, neurogenic niche construction, Neuronal Plasticity, oscillating gene networks, Peter Berean, physiology of reproduction, pre-mRNA, Public Evolution Summit, RNA-mediated amino acid substitutions, Schrodinger, secreting, self-organization, sensing, Sequence Selective Self-Repair, signaling, social niche construction, socio-cognitive niche construction, sunlight, supercoiled DNA, Top-down causation, Turing, UV-Induced Charge Transfer, Witzany

Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the […]

Optogenetics: Let there be virucidal light!

Nov 21, 2016James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, VariationsAnna Di Cosmo, autophagy, biophysically constrained, books, Bruce McEwen, diseases, diversity, dual-use technology, food odors, Greg Bear, interviews, John Hewitt, learning and memory, medicine, Mohamed Samir, mutations, natural selection, pathology, pheromones, protein folding chemistry, protein signaling, sci-fi, security, supercoiled DNA, terrorism, Virus-driven energy theft

NIH Awards $1.4M Grant to Support Optogenetics Research Excerpt: Synaptic plasticity, learning and memory are regulated by protein signaling in the brain. Many forms of learning disabilities and other mental diseases may be caused by abnormal protein signaling. To address these brain disorders and diseases, it is crucial to understand on a molecular level the […]

Nutrient-dependent autophagy

Oct 13, 2016James KohlAdaptations, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, Variations5hmCs, angstroms to ecosystems, ascorbate, atoms to ecosystems, autophagy, base pair changes, biophysically constrained, Calcium, cancers, cell memory, de novo Creation, Disease, ecological adaptations, enzymes, epigenetic memory, epigenetic memory erasure, food odors, genetic networks, hematopoietic malignancies, intracellular interactions, Iron, lead, manganese, metabolic networks, metal ions, methyl tags, nutrient-dependent, Nutrient-dependent autophagy, organizing base pair changes, organizing interactions throughout life, pheromone-controlled, Pheromone-controlled autophagy, physiology of reproduction, pluripotency, protein folding chemistry, receptor-mediated, Reprogramming, Retinol, RNA-mediated, single-base resolution, TET, TET2 mutations, Vitamin A. Vitamin C, Vitamin D, Vitamins A and C

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as […]