EDAR variant Archives - Autophagy

Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

Jun 18, 2018James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variationsbiologically uninformed theorists, Carl Zimmer, Chiara Gamberi, ecological adaptations, ecological variation, EDAR variant, Frank J. Slack, human idiocy, mutation-driven evolution, new definition of heredity, New York Times, Nutrient-dependent/pheromone-controlled adaptive evolution, RNA-mediated gene activation, Robin R. Gutell, rRNA, Sam Rodriques, Sickle Cell Mutation, V370A

Conclusion: …there are constraints on the mixed state entanglement… The biophysical constraints attest to the fact that quantum entanglement in photosynthetic complexes does not evolve. The works of two people who recently became members of the RNA-mediated FaceBook group attest to the overwhelming ignorance of biologically uninformed theorists. See for example: The C. elegans hunchback […]

Energy-dependent alternative splicings 1996 – 2016 (2)

Dec 31, 2016James KohlAdaptations, Alternative Splicings, Autophagy, Ecology, Model Organisms, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations1540T/C, 370A or Val370Ala, activity-dependent transcription, adaptability, adaptive evolution, anticodon recognition, autophagy, BDNF Val66Met, bio-functional information, bioactive agents, biocompatible component, biodiversity, biophysically constrained, cell type differentiation, Chromatin topology, co–enhancement, codon optimaility, COMT Val158Met, conditions of life, directed self-assembly, eccrine sweat gland, EDAR variant, energy-dependent autophagy, enzymes, epithelial-hybrid-mesenchymal fate determination, exonic variation, feedback loops, hair follicle density, hairy, healthy longevity, human facial variation, latent information, learning and memory, mesenchymal-epithelial signaling, microRNA flanking sequences, MicroRNA-based regulation, microRNA/messenger RNA balance, mRNA decoding, natural information processing, natural selection for codon optimality, negative entropy, neuronal gene expression, Non-coding RNAs, nsertion/deletion polymorphism, nutrient-dependent, odor, pheromone signaling, pheromone-controlled, pre-designed functions, reproduction, RNA-mediated, Rs3827760, self-assembly, self-organization, skin cells, supercoiled DNA, sweaty, tRNA modifications, Virus-driven energy theft

See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession […]

Sudden death indel polymorphism

Dec 19, 2016James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations1540T/C, 370A, adaptive variant, amino acid substitution, autophagy, base pair, bio-functional information, biophysically constrained, chromosome 2, ectodysplasin A receptor, EDAR gene, EDAR variant, energy-dependent, energy-dependent biodiversity, energy-dependent polymorphism, fixation, indel, insertion/deletion, John L. Leonard, knockin mouse, loss- and gain-of-function model, microRNA, mRNA, Peter Berean, physiology of reproduction, polymorphism, rs10692285, Rs3827760, single nucleotide polymorphism, sudden unexplained death, supercoiled DNA, Val370Ala

An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes […]

Light, behavior and autophagy, a gender-specific risk factor

Nov 22, 2016James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation"gender" specific risk factor., 23andMe, autophagy, base pair change, biophysically constrained, brain, brain plasticity, cell type differentiation, de novo Creation, EDAR variant, energy as information, G-protein-coupled receptors, galanin, genetic tweaks, genomic DNA, HPA-Axis Dysregulation, hydrogen-atom transfer in DNA base pairs in solution, intermediate S-states, microRNA/messenger RNA balance, morphology, mRNA degradation, nutrient-dependent pheromone-controlled, O2 evolution, one-electron photochemistry, oxygen-evolving complex, plasticity, receptor-mediated behavior, resynchronise, RNA-mediated, Rs3827760, rs948854, sensory characterization, sex as a biological variable, sex differences in the brain, sex-specific pathology, sexual differentiation, SNPs, supercoiled DNA, thermodynamic cycles, turnover, Val158Met, Val370Ala

Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery […]