DNA methylation Archives

RNA-mediated repurposing in microbes and adaptations in primate brains

Mar 9, 2015James KohlAlternative Splicings, Autophagy, Ecology, Human Pheromones, Model Organisms, RNA-directed DNA methylationAmino Acid, autophagy, brain stem cells, chimpanzees, DNA methylation, Dobzhansky, Evolutionary resurrection, gorilla, Human-specific gene, humans, natural selection, neocortex, nutrient-dependent, olfactory receptor gene, pheromone-controlled, repurposing, RNA-directed, RNA-mediated, substitution, Svante Paabo

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion Excerpt: “…the C-terminal 47 amino-acids of ARHGAP11B (after lysine-220) constitute not only a unique sequence, resulting from a frameshifting deletion (fig. S10), but also are functionally distinct from their counterpart in ARHGAP11A.” My comment: Co-author Svante Paabo is the senior author of this 2003 publication: […]