Can protein folding chemistry be understood by theorists?

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular […]

Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for […]

Mutations: the "driving force" behind human brain complexity?

Evolutionary Psychology Crap in New Scientist There is a reason why domestic violence is so widespread, says David Buss, an evolutionary biologist at the University of Texas in Austin: it carries a selective advantage, tied with reproductive success. Larry Moran wrote: There’s something seriously wrong with evolutionary psychology. And there’s something seriously wrong with respectable […]

Polycombic ecological adaptation as a science, not a theory

Multi-omic data integration enables discovery of hidden biological regularities   Excerpt: Tracing the central dogma of biology (left column), we can link specific data types (middle column) to explain each of these biological processes. In this work, novel biological regularities that relate these processes are discovered through: (i) primary omics data (top box, right column) […]

80 years of causal analysis (1936 – 2016)

Roles of Mutation and Selection in Speciation: From Hugo de Vries [1902 definition of mutation] to the Modern Genomic Era Excerpt: …mutation is crucial in speciation because reproductive barriers cannot be generated without mutations. My comment: Chromosomal rearrangements link autophagy from energy-dependent changes in RNA-mediated amino acid substitutions and supercoiled DNA to all biodiversity via […]

The natural success of RNAi and failed treatment

see my other blog posts on m6A Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Excerpt: …ZIKV infection alters m6A location in mRNAs, methylation motifs, and target genes modified by methyltransferases. Our results identify a mechanism by which ZIKV interacts with and alters host cell functions. Reported as: Zika virus infection alters […]

Hecatombic evolution via oncocers and oncohistones

Mutation-driven evolution is being replaced by a theory of hecatombic evolution that links oncocers and oncohistones to increasing organismal complexity via autophosphorylation and autophagy or something else as yet to be invented in the context of the new ridiculous theory. See for comparison: Polycomb enables primitive endoderm lineage priming in embryonic stem cells Abstract excerpt: […]

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