The energy-dependent creation of odorant receptors links single nucleotide polymorphisms and microRNAs to fixation of RNA-mediated amino acid substitutions that differentiate all cell types in all individuals or all living genera in the context of the physiology of pheromone-controlled reproduction.

We established that fact in our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation at a time when microRNAs were called pre-mRNAs. See our molecular epigenetics section:

Since then, these are some of the Nobel Laureates who have extended what is known about RNA-mediated cause and effect to what is known about all food energy-dependent pheromone-controlled biodiversity.

2004 Richard Axel (US) and Linda Buck (US) for their discoveries of “odorant receptors and the organization of the olfactory system.

2016: Yoshinori Ohsumi of Japan for his work on autophagy—a process whereby cells “eat themselves”—which when disrupted can cause Parkinson’s and diabetes.

2017: US geneticists Jeffrey Hall, Michael Rosbash and Michael Young for their discoveries on the internal biological clock that governs the wake-sleep cycles of most living things.

Nothing that happens in the life of any organism happens outside the context of the food energy-dependent biophysically constrained creation of ATP and RNA. All serious scientists know that, and their works have placed the facts about cell type differentiation into the context of feedback loops and messenger RNA cycling since 1990. See: Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Each time you see a report that indicates something new about energy-dependent feedback loops has been discovered, ask what the authors are trying to do. Keep this in mind, so that you know the answer:

“Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.” — Kalevi Kull–r_b_10797646.html

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4 years ago
Searching for the Mind

Excerpt: This is all very interrelated, complex and not clearly understood.

See my comment from October 2016.
It is clearly understood in the context of nutrient energy-dependent RNA-mediated ... See more

Effective autophagy helps us live longer and defective autophagy can increase aging.

4 years ago

4 years ago

"...biologists from The Rockefeller University have discovered that some cells rip themselves apart bit-by-bit in order to attract certain specialized proteins..."

My comment: They seem to think ... See more

4 years ago
Human Pheromones: Linking Neuroendocrinology and Ethology (revisited)

Leslie Vosshall wrote: 71.18 hr until my HHMI review talk. Just tossed half the slides. New simpler approach with more vision.
Here are the slides that I used to link subatomic particles to ... See more

Human Pheromones: Linking Neuroendocrinology and Ethology (revisited). International Society for Human Ethology, 2010 James V. Kohl Clinical Laboratory Scientist ASCP, ASCLS, AMT ... See more

4 years ago
The brain learns completely differently than we've assumed since the 20th century

"The brain learns completely differently than we've assumed since the 20th century" March 23, 2018

Excerpt: "The new ... See more

The brain is a complex network containing billions of neurons, where each of these neurons communicates simultaneously with thousands of other via their synapses (links). However, the neuron actually ... See more

4 years ago
Autophagy in health and disease (1) | RNA-Mediated

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed ... See more

4 years ago
Journals and Conferences on Genetics & Molecular Biology

Long before now the link from the sun's anti-entropic virucidal energy to the production of vitamin D and receptor-mediated healthy longevity should have consistently been placed into the context of ... See more

Association between Vitamin D Receptor Gene Polymorphism, Secondary Hyperparathyroidism and Ultrasound Densitometry Parameters in Postmenopausal ... See more

4 years ago
Greg Bear

Please note: This is probably the reason Timothy J. Cunningham from the CDC is missing. His publication history links the claims of the Republicans to refutations of neo-Darwinian nonsense. ... See more

In 2009, I pitched a threat idea to a major intelligence agency—behind closed doors—and suggested that the philosophical and moral collapse of modern conservatism would soon get dire enough to ... See more

4 years ago
Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

Death cured a theorist's Amyotrophic Lateral Sclerosis (ALS).

For comparison: A pathogenic mutation in D-amino acid oxidase (DAO) associated with familial ALS impairs D-serine metabolism and ... See more

We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAO[R199W] , associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine metabolism and causes protein ... See more

4 years ago
Here's how viruses inactivate the immune system, causing cancer - Colorado Cancer Blogs

Free full text: DNA Tumor Virus Regulation of Host DNA Methylation and Its Implications for Immune Evasion ... See more

Here’s how viruses inactivate the immune system, causing cancer by Garth Sundem | Mar 1, 2018 | Featured, Latest News, Research | 0 comments Sharon Kuss-Duerkop, PhD It’s no new news that viruses ... See more