Light-activated error free DNA repair (2)

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of […]

For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear […]

God vs host-derived creation of virus-driven pathology

Summary: The virus-driven theft of quantized energy forces cells to compete for nutrient energy-dependent RNA-mediated reprogramming in the context of the structure of photons, one-carbon metabolism, autophagy, and the physiology of reproduction, which links energy-dependent changes in chirality from base pairs to RNA-mediated amino acid substitutions. Host-derived viral transporter protein for nitrogen uptake in infected […]

Stem cells do not create themselves

Summary: The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not […]

Your indifference is killing you and others (3)

Summary: The speed of light on contact with water links the creation of microRNAs to Optical control of membrane tethering and interorganellar communication at nanoscales MicroRNA flanking sequences are linked to all biodiversity via hydrogen-atom transfer in DNA base pairs in solution. The physiology of reproduction links energy-dependent changes in the microRNA/messenger RNA balance to […]

Can protein folding chemistry be understood by theorists?

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular […]

Pattern recognition vs evolutionary processes (revisited)

Summary: Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer. That suggests the ignorance of pseudoscientists who fail to link pattern recognition from the food that organisms eat to the pheromone-controlled physiology of […]

Energy-dependent physical and biophysical constraints (9)

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin […]