Variations Archives - Autophagy

Autophagy-related microRNA-mediated disease treatment (1)

Aug 17, 2020James KohlAdaptations, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA interference, Variationsautoimmune diseases, autophagy regulation, Autophagy-Related Delivery, Dengue subgenomic RNA, diversity, ethnicity, how dengue virus adapts, inflammation, molecular mechanisms, Nanomaterials, naturally occurring autophagy, neoplastic transformation, Novel Cancer Treatments, oxidative stress, TRIM family regulatory region, vaccine-induced DNA damage, viral fragments, virus evolution, viruses

Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment Indexed on PubMed 8/16/20 This article is part of the Research Topic Novel Cancer Treatments based on Autophagy Modulation View all 11 Articles 1) “…understanding of the molecular mechanisms controlling autophagy…is still far from being elucidated.” That is a lie. Good questions lead towards understanding. Question: How […]

Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

Jun 18, 2018James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variationsbiologically uninformed theorists, Carl Zimmer, Chiara Gamberi, ecological adaptations, ecological variation, EDAR variant, Frank J. Slack, human idiocy, mutation-driven evolution, new definition of heredity, New York Times, Nutrient-dependent/pheromone-controlled adaptive evolution, RNA-mediated gene activation, Robin R. Gutell, rRNA, Sam Rodriques, Sickle Cell Mutation, V370A

Conclusion: …there are constraints on the mixed state entanglement… The biophysical constraints attest to the fact that quantum entanglement in photosynthetic complexes does not evolve. The works of two people who recently became members of the RNA-mediated FaceBook group attest to the overwhelming ignorance of biologically uninformed theorists. See for example: The C. elegans hunchback […]

Estranged ‘White Coat Notes’ blogger exposes human idiocy (1)

Jun 18, 2018James KohlAdaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsadaptations, alternative splicings, autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, model organisms, Neuronal Plasticity, Nutrigenomics, physics, RNA editing, RNA interference, RNA methylation, RNA-directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Scientific Discoveries, Subatomic, Variations, What’s in the News

Excerpt: Please pardon the overwhelming ignorance of those who failed to link what organisms eat from the quantized energy-dependent creation of microRNAs to healthy longevity via the pheromone-controlled physiology of reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from microbes to humans. The ignorance of biologically uninformed theorists has […]

The tipping point (revisited): 68,000 publications

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the Newsagriculture, Alphagenomix, Antiphage Defense Strategy, atoms to ecosystems, autophagy, cell type differentiation, classical physics, climate, creation of enzymes, drug metabolism, ecological adaptations, education, energy, food energy-dependent, funding, medical research, microRNA-mediated, microRNA-mediated gene expression, microRNAs, mutations, nutrient-dependent, pheromone-controlled, PLOSBLOGS, public health, quantum physics, regulation, Retraction Watch, scientific evidence, Trump administration, virus-driven degradation of messenger RNA, war on science

MicroRNA Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

Agilent technology and energy-dependent autophagy

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, Diseases & Disorders, Ecology, microRNA editing, RNA editing, RNA interference, VariationsAbcam, aerobic glycolysis, alternative splicings, Alzheimer's disease, Antiphage Defense Strategy, apoptosis, autophagy, Big Bang cosmology, bioenergetics, brain energy metabolism, Cancer, cancer immunotherapy, cell fate decision, Cognition, colon cancer, cryptic small proteins, death gene, embryonic stem cell differentiation, energy-dependent codon optimality l, epigenetic imprinting, Epigenetic modifications, epigenetically-effected, ER–mitochondrial coupling, glioblastoma, glycolysis during regeneration, H2S-producing enzymes, Hexokinase 2 mRNA stability, Immunity to Viral Infections, Mechanisms of Recombination, Metabolic Diseases, Microbiota, microRNAs, Mitochondrial Function, Nature Publications Group, neo-Darwinian nonsense, noncoding RNAs, OXIDATIVE PHOSPHORYLATION, oxidative stress, pheromones, physiology of reproduction, RNA cytosine methyltransferase, RNA-mediated, safe DNA repair, simultaneous measurement, stem cells, viral latency, virus infection

The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked to the prevention of the virus-driven degradation of messenger RNA […]

The Scientist reports Szostak’s “honest error”

Dec 20, 2017James KohlAdaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Top 10 Retractions of 2017 …Szostak’s lab could not reproduce the findings, which the group attributes to honest error. Please put the “honest error” into the perspective of what was reported in: Retraction Watch In retrospect, we were totally blinded by our belief [in our findings]… The claim that scientists were blinded by their belief […]

Trump challenges the CDC to remember 9/11

Dec 19, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations100th anniversary, American Legion, American Legion Riders, amino acid substitutions, antimutagenic effect, Biological Systems, biologically uninformed masses, blogosphere, Cancer, censorship, Center for Disease Control, complacency, diversity, economy, entitlement, Epigenetic modifications, epistasis, evidence-based, federal agency, federal budget, feedback loops, fetus, Forbidden Words, God and Country, Health and Human Services, influenza protein, Jack Szostak, meaningless words and phrases, Neil deGrasse Tyson, Obama, President Trump, Prevention, quantum effects, science-based, suicide, supercoiled DNA, transgender, trump, Trump administration, Viral Apocalypse, viral terror, virucidal ultraviolet light, virus-driven entropy, vulnerable

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending, you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

Narcissistic egomaniacal and deadly denial of autophagy

Dec 16, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsanti-suicidal nasal spray, ATP hydrolysis, autophagy, Bacterial, death gene, electrons to ecosystems, energy-dependent, estrogen-induced LH surge, excitons, feedback loop, free energy, glioblastoma, Gyrase, honeybee model organism, light-harvesting, microRNAs, negative supercoiling, neural stem cells, neurogenesis, pheromone-controlled, Pheromones.com, RNA-mediated.com, Subatomic.pro, supercoiled DNA, Viral and Metabolic Diseases, viral latency

Summary: Viral latency is food energy-dependent and pheromone-controlled in the context of autophagy, which protects organisms from the virus-driven degradation of messenger RNA. Workshop on Quantum Effects in Biological Systemshas established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology […]

Elsevier fails to support the concept of autophagy

Dec 15, 2017James KohlAlternative Splicings, Autophagy, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Nutrigenomics, RNA interference, RNA-mediated gene silencing, Variations, What's in the Newsanti-entropic virucidal energy of sunlight, cancer etiology, cancer prevention, chemical pathway, chemical's pathway, Codon optimality, communication, decay, electrons to ecosystems, electrostatic interactions, energy-dependent codon optimality, evolution, excitons, Glutamate Receptor Kinetics, healthy longevity, light, light-harvesting, light-harvesting systems, lysine residues, maternal-to-zygotic transition, natural selection, Nuclear RNAi, pheromone-controlled, physics, physiology of reproduction, premature death, presumptions, protein synthesis, quantum effects, Random DNA Copying ‘Mistakes’, RNA-mediated cell type differentiation, RNA-Mediated Control of Transcription, serious scientists, somatic mutations, Stem cell divisions, theorists, transgenerational epigenetic inheritance, translation, Trinucleotide Repeat Containing, unnecessary suffering

Summary: Who lets biologically uninformed theorists make presumptions about evolution after all serious scientists have linked light-harvesting from energy-dependent changes in electrons to ecosystems in all living genera via natural selection for food energy-dependent codon optimality. Who lets them pretend not to know that the pheromone-controlled physiology of reproduction links autophagy to the transgenerational epigenetic […]

Nature vs Science and Autophagy.pro

Dec 15, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variationsautophagy, biophysically constrained biodiversity, Calcium, Chloride, epistasis, feedback loops, fertility, Glucose, GnRH, gonadotropin-releasing hormone, healthy longevity, Hematocrit, Hemoglobin, hydrogen-atom transfer in DNA base pairs in solution, innate immune system, insects, intracellular signaling, intranuclear interactions, Lactic Acid, LH secretion, light, mammals, microbes, microRNA/messenger RNA balance, molecular epigenetics, nematodes, network of hydrogen bonds, nutritional epigenetics, pCO2, pH, pheromone-controlled, pO2, Potassium, potential of hydrogen, replication of viruses, selection for phenotype, single amino acid substitution, Sodium, stochastic gene expression, Virus-driven energy theft

Conclusion: The anti-entropic virucidal energy of sunlight links food energy directly from the innate immune system to all morphological and behavioral diversity. It all about energy. It’s all about the creation of enzymes. It’s all about the base pairs. Until the day that I launched Autophagy.pro, I had only one or two Facebook posts that […]