Energy-dependent autophagy prevents the degradation of messenger RNA

Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid […]

The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

The Scientist reports Szostak’s “honest error”

Top 10 Retractions of 2017 …Szostak’s lab could not reproduce the findings, which the group attributes to honest error. Please put the “honest error” into the perspective of what was reported in: Retraction Watch In retrospect, we were totally blinded by our belief [in our findings]… The claim that scientists were blinded by their belief […]

For God and Country

Trump challenges the CDC to remember 9/11

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending,  you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

Light-activated error free DNA repair (2)

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of […]

Long-term adaptation replaces evolution (2)

The food energy-dependent “doubling up” on ‘junk DNA’ is biophysically constrained by the physiology of pheromone-controlled reproduction. The metabolism of food to species-specific pheromones links the conserved molecular mechanisms of RNA-mediated cell type differentiation in all individuals of all living genera to healthy longevity via what is known about amino acid substitutions in supercoiled DNA, which […]

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