Pharmacogenomics Archives - Autophagy

The microRNA-mediated future of humanity (3)

Apr 24, 2020James Kohl1 CommentAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, RNA-mediated gene silencingautophagy inhibition, cancers, coronavirus, CRISPR, enhanced autophagy, enyzme-dependent endogenous substrates, food energy-dependent pheromone-controlled autophagy, intermolecular interaction, microRNA biogenesis, phages, proof of concept, sunlight, upstream regulators of gene expression

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper […]

Darwinian adaptation: a clear evolutionary trail?

Dec 22, 2017James KohlAdaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA editing, RNA interference, RNA-directed DNA methylation, Subatomicadaptability, anti-entropic virucidal energy, astrobiological question, autophagy, Bacterial self-organization, common sense, creation of sunlight, Darwinian adaptation, Dobzhansky, Eshel Ben-Jacob, feedback loops, Feynman, George F R Ellis, McEwen, microRNA-mediated creation, neo-Darwinian evolution, odor receptors, olfaction, physiology of reproduction, Psychology, Schrodinger, Socioaffective Neuroscience, supercoiled DNA, Top-down causation, viral latency, water

Summary: The light harvesting occurs in the ocean and on land. It links the creation of sunlight from food energy to the physiology of pheromone-controlled viral latency in all living genera, and all serious scientists know that. Origins of photosynthesis in plants dated to 1.25 billion years ago The world’s oldest algae fossils are […]

The tipping point (revisited): 68,000 publications

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the Newsagriculture, Alphagenomix, Antiphage Defense Strategy, atoms to ecosystems, autophagy, cell type differentiation, classical physics, climate, creation of enzymes, drug metabolism, ecological adaptations, education, energy, food energy-dependent, funding, medical research, microRNA-mediated, microRNA-mediated gene expression, microRNAs, mutations, nutrient-dependent, pheromone-controlled, PLOSBLOGS, public health, quantum physics, regulation, Retraction Watch, scientific evidence, Trump administration, virus-driven degradation of messenger RNA, war on science

MicroRNA Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

The Scientist reports Szostak’s “honest error”

Dec 20, 2017James KohlAdaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Top 10 Retractions of 2017 …Szostak’s lab could not reproduce the findings, which the group attributes to honest error. Please put the “honest error” into the perspective of what was reported in: Retraction Watch In retrospect, we were totally blinded by our belief [in our findings]… The claim that scientists were blinded by their belief […]

Trump challenges the CDC to remember 9/11

Dec 19, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations100th anniversary, American Legion, American Legion Riders, amino acid substitutions, antimutagenic effect, Biological Systems, biologically uninformed masses, blogosphere, Cancer, censorship, Center for Disease Control, complacency, diversity, economy, entitlement, Epigenetic modifications, epistasis, evidence-based, federal agency, federal budget, feedback loops, fetus, Forbidden Words, God and Country, Health and Human Services, influenza protein, Jack Szostak, meaningless words and phrases, Neil deGrasse Tyson, Obama, President Trump, Prevention, quantum effects, science-based, suicide, supercoiled DNA, transgender, trump, Trump administration, Viral Apocalypse, viral terror, virucidal ultraviolet light, virus-driven entropy, vulnerable

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending, you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

Narcissistic egomaniacal and deadly denial of autophagy

Dec 16, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsanti-suicidal nasal spray, ATP hydrolysis, autophagy, Bacterial, death gene, electrons to ecosystems, energy-dependent, estrogen-induced LH surge, excitons, feedback loop, free energy, glioblastoma, Gyrase, honeybee model organism, light-harvesting, microRNAs, negative supercoiling, neural stem cells, neurogenesis, pheromone-controlled, Pheromones.com, RNA-mediated.com, Subatomic.pro, supercoiled DNA, Viral and Metabolic Diseases, viral latency

Summary: Viral latency is food energy-dependent and pheromone-controlled in the context of autophagy, which protects organisms from the virus-driven degradation of messenger RNA. Workshop on Quantum Effects in Biological Systemshas established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology […]

Sal Giardina: apologetics revisited

Mar 27, 2017James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsautophagy, Charge Transfer, Codon optimality, consciousness, Coulomb barrier, Coulomb potentia, Coulombic, DNA, ecological adaptations, energy-dependent, Femtosecond blasts of UV light, femtosecond infrared spectroscopy, Fiona Macdonald, hecatombic, Hecatombic evolution, human love, hydrogen bonding groups in proteins, Hydrogen-Atom Transfer, Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution, James Pfaus, Jim Pfaus, Michael Baum, natural selection, organsm, origin of life, pathology, peptide mediated gene transfer activity, peptide self-association, pH, pH responsive, polycombic, polycombic ecological adaptations, RNA-directed DNA methylation, RNA-mediated cell type differentiation, RNA-mediated DNA repair, Sal Giardina, secular humanists, Self-Repair, Sequence Selective, Single nucleotide substitutions, Ultraviolet Absorption, UV-Induced, virucidal energy, Virus-driven energy theft, virus-driven evolution

March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue […]

Natural selection for codon optimality and quantum viruses

Feb 6, 2017James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsautophagy, biodiversity, biophysically constrained, cellular degradation, endogenous RNA interference, imino photons, Matti Pitkänen, messenger RNA degradation, microRNA precursor, microRNA/messenger RNA, microRNAs, protein folding chemistry, residues, RNA-mediated amino acid substitutions, temperature-responsive flowering, tipping point, Virus-driven energy theft

Life is Quantum Life is energy-dependent. Energy is information. Life is not quantum except in the context of hydrogen-atom energy transfer in DNA base pairs in solution. Claims that do not also address the effects of virus-driven energy theft fail to link what is know about quantum physics from the creation of the sun to […]

Energy-dependent oscillating gene networks organize life

Dec 26, 2016James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsalternative RNA splicings, alternative splicing techniques of pre-mRNA, autophagy, bio-functional information, biodiversity, cellular intelligence, DNA repair, energy as information, energy is information, epigenetic influences, experimental evidence, food odors, G-protein-coupled receptors, Human Pheromones, immune system, Jon Lieff, Mazur, mutation-initiated, natural selection, neurogenic niche construction, Neuronal Plasticity, oscillating gene networks, Peter Berean, physiology of reproduction, pre-mRNA, Public Evolution Summit, RNA-mediated amino acid substitutions, Schrodinger, secreting, self-organization, sensing, Sequence Selective Self-Repair, signaling, social niche construction, socio-cognitive niche construction, sunlight, supercoiled DNA, Top-down causation, Turing, UV-Induced Charge Transfer, Witzany

Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the […]

Energy-dependent purifying selection / autophagy (2)

Nov 21, 2016James KohlAdaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, Variationsautism, autophagy, biophysically constrained, brain development, cell type differentiation, chemistry, CRISPR Bioterror Threat, CRISPR edited cells, Dinosaurs Gone Soft, Gender Differences, Greg Bear, molecular epigenetics, physics, physiology of reproduction, pseudoscientific nonsense, purifying selection, RNA-mediated cell type differentiation, RNA-mediated changes, Shared epigenetic changes, Single-Cell Gene Expression, social scientists, syndrome-defining traits, Teresa Binstock, The Darwin Code

See: Energy-dependent purifying selection / autophagy Thanks to Teresa Binstock for alerting me to this example, which was reported as: Shared epigenetic changes underlie different types of autism. Teresa wrote: “You might enjoy a glance at a use of epigenetic technology. Findings begin to answer, why such syndrome-defining traits given such diverse inter-individual genetics and […]