Neuronal Plasticity Archives - Autophagy

The tipping point (revisited): 68,000 publications

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the Newsagriculture, Alphagenomix, Antiphage Defense Strategy, atoms to ecosystems, autophagy, cell type differentiation, classical physics, climate, creation of enzymes, drug metabolism, ecological adaptations, education, energy, food energy-dependent, funding, medical research, microRNA-mediated, microRNA-mediated gene expression, microRNAs, mutations, nutrient-dependent, pheromone-controlled, PLOSBLOGS, public health, quantum physics, regulation, Retraction Watch, scientific evidence, Trump administration, virus-driven degradation of messenger RNA, war on science

MicroRNA Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

Trump challenges the CDC to remember 9/11

Dec 19, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations100th anniversary, American Legion, American Legion Riders, amino acid substitutions, antimutagenic effect, Biological Systems, biologically uninformed masses, blogosphere, Cancer, censorship, Center for Disease Control, complacency, diversity, economy, entitlement, Epigenetic modifications, epistasis, evidence-based, federal agency, federal budget, feedback loops, fetus, Forbidden Words, God and Country, Health and Human Services, influenza protein, Jack Szostak, meaningless words and phrases, Neil deGrasse Tyson, Obama, President Trump, Prevention, quantum effects, science-based, suicide, supercoiled DNA, transgender, trump, Trump administration, Viral Apocalypse, viral terror, virucidal ultraviolet light, virus-driven entropy, vulnerable

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending, you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

Narcissistic egomaniacal and deadly denial of autophagy

Dec 16, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsanti-suicidal nasal spray, ATP hydrolysis, autophagy, Bacterial, death gene, electrons to ecosystems, energy-dependent, estrogen-induced LH surge, excitons, feedback loop, free energy, glioblastoma, Gyrase, honeybee model organism, light-harvesting, microRNAs, negative supercoiling, neural stem cells, neurogenesis, pheromone-controlled, Pheromones.com, RNA-mediated.com, Subatomic.pro, supercoiled DNA, Viral and Metabolic Diseases, viral latency

Summary: Viral latency is food energy-dependent and pheromone-controlled in the context of autophagy, which protects organisms from the virus-driven degradation of messenger RNA. Workshop on Quantum Effects in Biological Systemshas established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology […]

Light-activated error free DNA repair (2)

Nov 22, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, VariationsA-to-I RNA editing, A2AR, achiral glycine, adenosine repletion, atoms to ecosystems, autophagy, chiral source of hydrogen atoms, curcumin, de novo changes in electrons, docosahexaenoic acid, ecological adaptations, Endogenous adenosine, energy-dependent, error-free RNA-mediated DNA repair, GnRH decapeptide, Mechanisms of Recombination, Neuroimmunology, neurological disorders, Niacinamide, Nicotinamide, nucleotides, osteoarthritis, pheromone-controlled reproduction, photoreductant source, physiology, production of nucleotides, quantized energy, recombination, ribonucleotide reductase, RNA editing, RNA-mediated, sunlight, supercoiled DNA, virus-driven degradation of messenger RNA

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of […]

Energy-dependent structure and function: Until death (1)

Oct 11, 2017James KohlAutophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variationsachiral glycine, agonist-induced changes, allosteric inhibition, antiviral response, ATP dependent, autophagy, BDNF Val66Met substitution, biophysically constrained vertebrate biodiversity, Bruce McEwen, Bull Sperm MicroRNAome, Circulating microRNA, dizocilpine, ecological variation, energy landscape, environment, epigenesis, epistasis, Evolutionary distance measurements, extracellular domain, feedback loops, Fescue Toxicosis, food odors, gating motions, genes, Genes/Domains identification, glycolysis, GnRH, GnRH receptor, gonadotropin-releasing hormone, human-specific COMT Val158Met substitution, Implementing sequence statistics, kinetic changes, NMDA receptor gating, Nobel Peace Prize, oxidative carbohydrate catabolism, OXIDATIVE PHOSPHORYLATION, pheromones, Phylogenetic tree building methods, Phylogenetic tree evaluation, physiology of reproduction, pre-stressed translational signature, Replication defective viral genomes, resonance energy transfer, RNA SYNTHESIS, RNA-mediated, Selection confirmation, Sequence alignments, sex, Sperm MicroRNA Expression, structurally distinct changes, structure-energy landscape, suicide, Suicide Prevention, transcriptome’s response, transmembrane states, virus-driven degradation of messenger RNA, Viruses in Human Semen, zinc

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear […]

Stem cells do not create themselves

Aug 17, 2017James KohlAdaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variationsautophagy, energy-dependent, epithelial stem cell dynamics, homeostasis, microRNA, niche construction, pheromone-controlled, stem cells, stromal niche cells, tissue integrity, virus-driven degradation of messenger RNA

Summary: The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not […]

Can protein folding chemistry be understood by theorists?

Aug 3, 2017James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsatoms to ecosystems, ATP dependent, autophagy, Bruce McEwen, Cancer Mutations, chirality, chromosomal rearrangements, cological niche construction, ctenophore, de novo Creation, Denise Chen, DNA Folding, DNA structure, Donald Pfaff, ecological adaptations, energy-dependent, evolution of intelligence, GnRH, Gut viruses, hematopoiesis, isoforms, Martha McClintock, microRNA / messenger RNA balance, Moroz, neo-Darwinian evolution, neurogenic niche construction, niche construction, non-inherited genetic change, physiology of pheromone-controlled reproduction, quantum physics, Quantum Souls, RNA SYNTHESIS, RNA-mediated, Robert L. Moss, secondary loss of neurons and synapses, social niche construction, socio-cognitive niche construction, Textbook Model, tumor viruses, uncontrolled cell growth, virus-driven degradation of messenger RNA, Wen Zhou

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular […]

MicroRNAs GnRH and the failure of sex research

Jun 16, 2017James KohlAdaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, VariationsAdkins-Regan, alternative splicing, anti-entropic virucidal energy, Archives of Sexual Behavior, atoms to ecosystems, automagically assemble, autophagy, Bakker, Balthazart, Baum, biodiversity, Breedlove, chirality, chromosomal inheritance, de novo Creation, de novo creation of microRNAs, energy-dependent RNA-mediated cell type differentiation, Evidentiary Convergence, feedback loops, fertility, flanking sequences, Helicity, human idiocy, Human Sexual Orientation, hypothalamic control, LeVay, McFadden, microRNA flanking sequences, microRNA-mediated cause and effect, microRNAs, molecular epigenetics, mutations, odor, pathology, pheromone signaling, pheromone-controlled physiology of reproduction, pre-mRNA, pseudoscientists, quantized energy-dependent, sexual differentiation, social scientists, ultraviolet light, virus-driven degradation of messenger RNA

Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs […]

Functionally interdependent editing and methylation

Apr 4, 2017James KohlAdaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsanticodon loop, autophagy, Billion Dollar Baby, chirality, de novo Creation, deaminase ADAT2/3, editing, endogenous viral elements, energy-dependent codon optimality, feedback loops, flanking sequences, food odors, functionally interdependent, guardian RNAs, human codon-optimized, hydrogen-atom transfer in DNA base pairs in solution, irus-driven energy theft, light, luteinizing hormone, m3C methyltransferase, Methylation, microRNA, microRNAs, mRNA stability, mutagenic enzyme, mutagenicity, natural selection for energy-dependent codon optimality, neurogenesis, OXIDATIVE PHOSPHORYLATION, pheromones, physiology of reproduction, protein conjugation, RNA interference, RNA-directed DNA methylation, RNAi, supercoiled DNA, Supramolecular Assembly, synthesis of RNA, Virus-driven energy theft

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C […]

Sal Giardina: apologetics revisited

Mar 27, 2017James KohlAdaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variationsautophagy, Charge Transfer, Codon optimality, consciousness, Coulomb barrier, Coulomb potentia, Coulombic, DNA, ecological adaptations, energy-dependent, Femtosecond blasts of UV light, femtosecond infrared spectroscopy, Fiona Macdonald, hecatombic, Hecatombic evolution, human love, hydrogen bonding groups in proteins, Hydrogen-Atom Transfer, Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution, James Pfaus, Jim Pfaus, Michael Baum, natural selection, organsm, origin of life, pathology, peptide mediated gene transfer activity, peptide self-association, pH, pH responsive, polycombic, polycombic ecological adaptations, RNA-directed DNA methylation, RNA-mediated cell type differentiation, RNA-mediated DNA repair, Sal Giardina, secular humanists, Self-Repair, Sequence Selective, Single nucleotide substitutions, Ultraviolet Absorption, UV-Induced, virucidal energy, Virus-driven energy theft, virus-driven evolution

March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue […]