Preprints obfuscate facts (3)

See: Preprints obfuscate facts (1) from RNA-mediated.com and Preprints obfuscate facts (2) from MicroRNA.pro Photoperiod-dependent expression of MicroRNA in Drosophila (11/6/18) is one of 2173 search results for “microRNA” at @biorxivpreprints. All results can be compared to >83,500 published works from this PubMed search for microRNA The PubMed search links the energy-dependent creation of achiral […]

Autophagy automagically prevents cancer (2)

Study suggests how high blood pressure might contribute to Alzheimer’s 1/28/19, and this report on another article from the same issue of  Nature Communications on 11/19/18 was also reported on 1/28/19 as New knowledge about the interactions of messenger RNAs and micro-RNAs during brain development …imbalance between cell types… can lead to this disease… and… […]

Autophagy automagically prevents cancer (1)

microRNA + autophagy See items 1-1088 See also: MicroRNA.pro Autophagic cell death restricts chromosomal instability during replicative crisis 1/23/19 …autophagy is an integral component of the tumour suppressive crisis mechanism and that loss of autophagy function is required for the initiation of cancer. Reported as: In surprising reversal, scientists find a cellular process that stops […]

Quantized energy-dependent microRNA-mediated autophagy (2)

Summary: A single genetic change provided complete protection against an invariably lethal dementia. A naturally occurring variant of the human prion protein completely prevents prion disease (2015) …mice expressing only PrP V127 were completely resistant to all prion strains, demonstrating a different molecular mechanism to M129V, which provides its relative protection against classical CJD and […]

Quantized energy-dependent microRNA-mediated autophagy

How to stop virus-driven activation of your death genes. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (2011) See: Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death (2018) Reported as:  Is it possible to kill cancer […]

Energy-dependent autophagy prevents the degradation of messenger RNA

Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid […]

The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]