The last RNA-mediated theory killer (2)

Autophagy (epigenetically effected by nutrient-energy and controlled by the physiology of reproduction) See for comparison: Virus-driven energy theft and epigenetically-effected autophagy Selleck Chem product use citations Excerpts: Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses. A causal link […]

Asking the right questions (2)

See first: Asking the right questions (1) I reiterate: My comment: The Journal of Molecular Biology topic is “Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors.” The authors have linked energy-dependent changes from angstroms to ecosystems via the conserved molecular mechanism of autophagy. The mechanisms link the innate immune system of bacteria to […]

RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled

 Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Excerpt: The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2). Reported as: Evolutionary Rewiring Strong selective pressure can lead to […]

Biophysically constrained beginnings of RNA and DNA

Any anonymous participant in the discussion of: DNA may have had humble beginnings as nutrient carrier (Sep 01, 2014 by Adam Hadhazy) asks: “when are you going to keep quiet?” In a series of responses, I have explained the problem I have with honoring his request. The following excerpts from Wikipedia and other sources are […]