base editing Archives - Autophagy

The microRNA-mediated future of humanity (3)

Apr 24, 2020James Kohl1 CommentAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, RNA-mediated gene silencingautophagy inhibition, cancers, coronavirus, CRISPR, enhanced autophagy, enyzme-dependent endogenous substrates, food energy-dependent pheromone-controlled autophagy, intermolecular interaction, microRNA biogenesis, phages, proof of concept, sunlight, upstream regulators of gene expression

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper […]

The tipping point (revisited): 100K (2)

Apr 1, 2020James Kohl2 CommentsAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA interference, Subatomicamino acid substitutions, atheists, cell type differentiation, Codon optimality, endogenous RNA interference, OXIDATIVE PHOSPHORYLATION, pseudoscientists, RNA SYNTHESIS, theorists

See first: The tipping point (revisited): 100K (1) 3/30/20 Excerpts: MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. Moving forward: Why do dozens of diseases wax and wane with the […]

Trump-hating advocates of vaccines + GMOs (3)

Jun 7, 2019James Kohl1 CommentAdaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Model Organismsamino acid identity, GMOs, microRNA-RNA-peptide nanocomplex, peptide bond formation, theorists, vaccines

MicroRNA.pro: Trump-hating advocates of vaccines + GMOs (1) RNA-mediated.com: Trump-hating advocates of vaccines + GMOs (2) microRNA + autophagy See items 1-1204 Scientific creationists from the Institute for Creation Research (ICR) and biologically uninformed neo-Darwinian theorists from Oded Rechavi’s group in Israel have helped Trump-hating advocates of vaccines + GMOs in the same way. They […]

Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

Jun 18, 2018James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variationsbiologically uninformed theorists, Carl Zimmer, Chiara Gamberi, ecological adaptations, ecological variation, EDAR variant, Frank J. Slack, human idiocy, mutation-driven evolution, new definition of heredity, New York Times, Nutrient-dependent/pheromone-controlled adaptive evolution, RNA-mediated gene activation, Robin R. Gutell, rRNA, Sam Rodriques, Sickle Cell Mutation, V370A

Conclusion: …there are constraints on the mixed state entanglement… The biophysical constraints attest to the fact that quantum entanglement in photosynthetic complexes does not evolve. The works of two people who recently became members of the RNA-mediated FaceBook group attest to the overwhelming ignorance of biologically uninformed theorists. See for example: The C. elegans hunchback […]

Estranged ‘White Coat Notes’ blogger exposes human idiocy (1)

Jun 18, 2018James KohlAdaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsadaptations, alternative splicings, autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, model organisms, Neuronal Plasticity, Nutrigenomics, physics, RNA editing, RNA interference, RNA methylation, RNA-directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Scientific Discoveries, Subatomic, Variations, What’s in the News

Excerpt: Please pardon the overwhelming ignorance of those who failed to link what organisms eat from the quantized energy-dependent creation of microRNAs to healthy longevity via the pheromone-controlled physiology of reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from microbes to humans. The ignorance of biologically uninformed theorists has […]

The tipping point (revisited): 68,000 publications

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the Newsagriculture, Alphagenomix, Antiphage Defense Strategy, atoms to ecosystems, autophagy, cell type differentiation, classical physics, climate, creation of enzymes, drug metabolism, ecological adaptations, education, energy, food energy-dependent, funding, medical research, microRNA-mediated, microRNA-mediated gene expression, microRNAs, mutations, nutrient-dependent, pheromone-controlled, PLOSBLOGS, public health, quantum physics, regulation, Retraction Watch, scientific evidence, Trump administration, virus-driven degradation of messenger RNA, war on science

MicroRNA Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

Agilent technology and energy-dependent autophagy

Dec 21, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, Diseases & Disorders, Ecology, microRNA editing, RNA editing, RNA interference, VariationsAbcam, aerobic glycolysis, alternative splicings, Alzheimer's disease, Antiphage Defense Strategy, apoptosis, autophagy, Big Bang cosmology, bioenergetics, brain energy metabolism, Cancer, cancer immunotherapy, cell fate decision, Cognition, colon cancer, cryptic small proteins, death gene, embryonic stem cell differentiation, energy-dependent codon optimality l, epigenetic imprinting, Epigenetic modifications, epigenetically-effected, ER–mitochondrial coupling, glioblastoma, glycolysis during regeneration, H2S-producing enzymes, Hexokinase 2 mRNA stability, Immunity to Viral Infections, Mechanisms of Recombination, Metabolic Diseases, Microbiota, microRNAs, Mitochondrial Function, Nature Publications Group, neo-Darwinian nonsense, noncoding RNAs, OXIDATIVE PHOSPHORYLATION, oxidative stress, pheromones, physiology of reproduction, RNA cytosine methyltransferase, RNA-mediated, safe DNA repair, simultaneous measurement, stem cells, viral latency, virus infection

The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked to the prevention of the virus-driven degradation of messenger RNA […]

Trump challenges the CDC to remember 9/11

Dec 19, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations100th anniversary, American Legion, American Legion Riders, amino acid substitutions, antimutagenic effect, Biological Systems, biologically uninformed masses, blogosphere, Cancer, censorship, Center for Disease Control, complacency, diversity, economy, entitlement, Epigenetic modifications, epistasis, evidence-based, federal agency, federal budget, feedback loops, fetus, Forbidden Words, God and Country, Health and Human Services, influenza protein, Jack Szostak, meaningless words and phrases, Neil deGrasse Tyson, Obama, President Trump, Prevention, quantum effects, science-based, suicide, supercoiled DNA, transgender, trump, Trump administration, Viral Apocalypse, viral terror, virucidal ultraviolet light, virus-driven entropy, vulnerable

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending, you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

Narcissistic egomaniacal and deadly denial of autophagy

Dec 16, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the Newsanti-suicidal nasal spray, ATP hydrolysis, autophagy, Bacterial, death gene, electrons to ecosystems, energy-dependent, estrogen-induced LH surge, excitons, feedback loop, free energy, glioblastoma, Gyrase, honeybee model organism, light-harvesting, microRNAs, negative supercoiling, neural stem cells, neurogenesis, pheromone-controlled, Pheromones.com, RNA-mediated.com, Subatomic.pro, supercoiled DNA, Viral and Metabolic Diseases, viral latency

Summary: Viral latency is food energy-dependent and pheromone-controlled in the context of autophagy, which protects organisms from the virus-driven degradation of messenger RNA. Workshop on Quantum Effects in Biological Systemshas established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology […]

Nature vs Science and Autophagy.pro

Dec 15, 2017James KohlAdaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variationsautophagy, biophysically constrained biodiversity, Calcium, Chloride, epistasis, feedback loops, fertility, Glucose, GnRH, gonadotropin-releasing hormone, healthy longevity, Hematocrit, Hemoglobin, hydrogen-atom transfer in DNA base pairs in solution, innate immune system, insects, intracellular signaling, intranuclear interactions, Lactic Acid, LH secretion, light, mammals, microbes, microRNA/messenger RNA balance, molecular epigenetics, nematodes, network of hydrogen bonds, nutritional epigenetics, pCO2, pH, pheromone-controlled, pO2, Potassium, potential of hydrogen, replication of viruses, selection for phenotype, single amino acid substitution, Sodium, stochastic gene expression, Virus-driven energy theft

Conclusion: The anti-entropic virucidal energy of sunlight links food energy directly from the innate immune system to all morphological and behavioral diversity. It all about energy. It’s all about the creation of enzymes. It’s all about the base pairs. Until the day that I launched Autophagy.pro, I had only one or two Facebook posts that […]