A model of ecological adaptation

Autophagy-related microRNA-mediated disease treatment (1)

Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment Indexed on PubMed 8/16/20 This article is part of the Research Topic Novel Cancer Treatments based on Autophagy Modulation View all 11 Articles  1)  “…understanding of the molecular mechanisms controlling autophagy…is still far from being elucidated.” That is a lie. Good questions lead towards understanding. Question: How […]

The microRNA-mediated future of humanity (3)

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper […]

The tipping point (revisited): 100K (2)

See first: The tipping point (revisited): 100K (1) 3/30/20 Excerpts: MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. Moving forward: Why do dozens of diseases wax and wane with the […]

A model of ecological adaptation

Trump-hating advocates of vaccines + GMOs (3)

MicroRNA.pro: Trump-hating advocates of vaccines + GMOs (1) RNA-mediated.com: Trump-hating advocates of vaccines + GMOs (2) microRNA + autophagy See items 1-1204 Scientific creationists from the Institute for Creation Research (ICR) and biologically uninformed neo-Darwinian theorists from Oded Rechavi’s group in Israel  have helped Trump-hating advocates of vaccines + GMOs in the same way. They […]

Preprints obfuscate facts (3)

See: Preprints obfuscate facts (1) from RNA-mediated.com and Preprints obfuscate facts (2) from MicroRNA.pro Photoperiod-dependent expression of MicroRNA in Drosophila (11/6/18) is one of 2173 search results for “microRNA” at @biorxivpreprints. All results can be compared to >83,500 published works from this PubMed search for microRNA The PubMed search links the energy-dependent creation of achiral […]

Autophagy automagically prevents cancer (2)

Study suggests how high blood pressure might contribute to Alzheimer’s 1/28/19, and this report on another article from the same issue of  Nature Communications on 11/19/18 was also reported on 1/28/19 as New knowledge about the interactions of messenger RNAs and micro-RNAs during brain development …imbalance between cell types… can lead to this disease… and… […]

Autophagy automagically prevents cancer (1)

microRNA + autophagy See items 1-1088 See also: MicroRNA.pro Autophagic cell death restricts chromosomal instability during replicative crisis 1/23/19 …autophagy is an integral component of the tumour suppressive crisis mechanism and that loss of autophagy function is required for the initiation of cancer. Reported as: In surprising reversal, scientists find a cellular process that stops […]

Quantized energy-dependent microRNA-mediated autophagy (2)

Summary: A single genetic change provided complete protection against an invariably lethal dementia. A naturally occurring variant of the human prion protein completely prevents prion disease (2015) …mice expressing only PrP V127 were completely resistant to all prion strains, demonstrating a different molecular mechanism to M129V, which provides its relative protection against classical CJD and […]

Quantized energy-dependent microRNA-mediated autophagy

How to stop virus-driven activation of your death genes. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (2011) See: Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death (2018) Reported as:  Is it possible to kill cancer […]

Energy-dependent autophagy prevents the degradation of messenger RNA

Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid […]