Quantized energy-dependent microRNA-mediated autophagy (2)

Summary: A single genetic change provided complete protection against an invariably lethal dementia. A naturally occurring variant of the human prion protein completely prevents prion disease (2015) …mice expressing only PrP V127 were completely resistant to all prion strains, demonstrating a different molecular mechanism to M129V, which provides its relative protection against classical CJD and […]

Quantized energy-dependent microRNA-mediated autophagy

How to stop virus-driven activation of your death genes. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (2011) See: Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death (2018) Reported as:  Is it possible to kill cancer […]

Energy-dependent autophagy prevents the degradation of messenger RNA

Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid […]

The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

Agilent technology and energy-dependent autophagy

The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the  technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked  to the prevention of the virus-driven degradation of messenger RNA […]

The Scientist reports Szostak’s “honest error”

Top 10 Retractions of 2017 …Szostak’s lab could not reproduce the findings, which the group attributes to honest error. Please put the “honest error” into the perspective of what was reported in: Retraction Watch In retrospect, we were totally blinded by our belief [in our findings]… The claim that scientists were blinded by their belief […]

For God and Country

Trump challenges the CDC to remember 9/11

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending,  you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who […]

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