James Vaughn KohlJames Vaughn Kohl
James Vaughn Kohl was one of the first to accurately conceptualize how energy-dependent RNA-mediated cell type differentiation occurs in the context of the pheromone-controlled physiology of reproduction. After 10 years of literature reviews, he began presenting his findings to the scientific community in 1992. He continues to disseminate accurate information to diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualizations and model of energy-dependent biophysically constrained RNA-mediated biologically-based cause and effect. Kohl has integrated experimental evidence that pinpoints the de novo creation of an ecologically adapted neurophysiological mechanism, which other serious scientists have linked from olfactory/pheromonal input to gene activation in hormone-secreting cells of tissue in a specific area of the brain (i.e., the hypothalamus). Ecological variation is linked to ecological adaptations via the sensory integration of olfactory and visual input, which determines how behavioral development leads to the development of personal preferences for food and to the development of preferences for other people. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by distinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for expertise in neuroscience, and his 2007 “Reiss Theory” award was for expertise in social science. Additional published works have continued to link social science to pseudoscience via what is currently known about nutritional epigenetics, food odors, and human pheromones. Food odors and pheromones link conserved molecular mechanisms of cell type differentiation from ecological variation to RNA-mediated cell type differentiation and ecological adaptions in species from microbes to man.


Kohl worked as a medical laboratory scientist from 1974 until 2013, and he devoted more than twenty-nine of those thirty-nine years to researching the relationship between the sense of smell and cell type differentiation, which he linked to life history transitions that include the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. That fact led Kohl to recognize how nutrient energy-dependent pheromone-controlled cell type differentiation enables ecological variation to be linked to epigenetically effected cell type differentiation in all cells of all tissues in all organs of all organ systems in all organisms via conserved molecular mechanisms.

James V. Kohl is certified as a Medical Laboratory Scientist with:

James V. Kohl is a member of:

Kohl is a former member or emeritus member of:

* Asterisks indicate approximately how many times Kohl has presented at an annual meeting.

Virtual conferences allow Kohl to present information from the comfort of his home.  There has been no need to waste money on conference attendance since the time a presenter revealed the fact that every aspect of cell type differentiation occurs downstream from energy-dependent changes in the microRNA/messenger RNA balance.

MicroRNAs were called pre-mRNAs in 1996. See: Diamond M, Binstock T, Kohl JV. From fertilization to adult sexual behavior. Horm Behav. 1996 Dec;30(4):333-53. (Authors’ copy here.)

See our section on molecular epigenetics:

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

In 1994, Eugene Daev published: Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

The fact the food odors and pheromones biophysically constrain energy-dependent RNA-mediated autophagy has since become perfectly clear to all serious scientists. For details, see:

5/8/17 Energy as information and constrained endogenous RNA interference

7/31/16 From hydrogen atom transfer in DNA base pairs to ecosystems

7/31/16 RNA-mediated physics, chemistry, and molecular epigenetics

7/30/16 What is life when it is not protected from virus driven entropy

7/29/16 RNA-mediated molecular epigenetics and virus-driven entropy

4/10/14 Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

8/8/13 Nutrient-dependent / pheromone-controlled adaptive evolution

3/8/13 Nutrient-dependent / Pheromone–controlled thermodynamics and thermoregulation

2/17/13 Nutrient-dependent / Pheromone-controlled Adaptive Evolution

See also:

Kohl, J.V. (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology, 3: 20553.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

Unpublished (invited review of nutritional epigenetics for the journal Nutrients)

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Selected Presentations:

Nutrient-dependent / Pheromone-controlled adaptive evolution: (a mammalian model of thermodynamics and organism-level thermoregulation) 5.5 minute video presentation

See also: Nutrient-dependent/pheromone-controlled adaptive evolution

Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior

Human pheromones, epigenetics, physiology, and the development of animal behavior

Human Pheromones: The Mind’s Eyes and behavior (videos from my 2010 presentation to Mensa)

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