microRNA + autophagy See items 1-1088 See also: MicroRNA.pro

Autophagic cell death restricts chromosomal instability during replicative crisis 1/23/19

…autophagy is an integral component of the tumour suppressive crisis mechanism and that loss of autophagy function is required for the initiation of cancer.

Reported as: In surprising reversal, scientists find a cellular process that stops cancer before it starts

 … a surprising discovery: a cellular recycling process called autophagy—generally thought of as a survival mechanism—actually promotes the death of cells, thereby preventing cancer initiation.

…occasionally, due to cancer-causing viruses or other factors, cells don’t get the message and keep on dividing.

…we didn’t know autophagy is involved with the cell death in crisis; we certainly didn’t know how autophagy prevents the accumulation of genetic damage. This opens up a completely new field of research we are eager to pursue.

The virus-driven degradation of messenger RNA causes mutations, which are linked to the loss of autophagy and all pathology. In the journal article about Autophagic cell death, they admit that cancer treatments to inhibit autophagy probably increased the frequency of virus-driven neoplastic transformation.

Simply put, the ineffective treatments caused more cancers. What more can be said for effective treatments that link food energy to biophysically constrained viral latency and healthy longevity via transgenerational epigenetic inheritance?

See: Energy as information and constrained endogenous RNA interference

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.

Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution.

The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

Competition for private funding led to claims from the Institute for Creation Research about continuous environmmenttal tracking and immanent selection (February 2019).

Competition for government funding led to claims about The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules 1/25/19

Dynamical emergence and immanent selection are linked to:

Adaptive modular hierarchical structures

Adaptation to context

Circular logic:

…higher level processes to determine what occurs at the lower levels in order to adapt them to higher level needs…

Adaptive selection

Genotypes that get

…selected when adaptation takes place.

Darwinian adaptive selection (aka Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations.)

inter alia (among other things) types of adaptation in the context of the adaptive immune system

the adaptive Bayesian brain

adaptive learning processes

adaptive modular hierarchical networks

and

“…the origin of life out of a physical substratum, when both metabolic and adaptive evolutionary processes first [automagically] came into being.

In The Dynamical Emergence of Biology From Physics, the authors admit: We do not know how that occurred.”

In the context of the Institute for Creation Research’s model of continuous environmental tracking,  immanent selection links God’s Creation of viruses to something other than all diseases.

When I challenged his claim that there is no such thing as natural selection by providing evidence that natural selection for energy-dependent codon optimality protects all organized genomes from the virus-driven degradation of messenger RNA and the mutations linked to all diseases Henry Morris IV unfriended me on Facebook.

After he unfriended me on Facebook, Henry Morris IV wrote:

For the first time in my FB “career” I’ve been forced to block someone for multiple false claims and insinuations against the excellent work of ICR. I’m usually quite gracious and longsuffering in such situations–perhaps to a fault. But there comes a time when you just have to “shake off the dust from your feet” (Matthew 10:14) and move on.

The excellent work of ICR and the works of George FR Ellis parallel precisely my history of publications and presentations with one exception. Their research does not show that natural selection for food and the physiology of reproduction protects all organisms from virus-driven pathology via what is known about Phytoremediation, Microbiome and CRISPR (1) and Phytoremediation, Microbiome and CRISPR (2).

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  1. Pingback: Autophagy automagically prevents cancer (2) - Autophagy

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