Summary: The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not create themselves.

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

1) The constant regeneration of stomach epithelium is driven by long-lived stem cells1, 2, 3, but the mechanism that regulates their turnover is not well understood.

2) The ability of stromal niche cells to control and adapt epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial regeneration and maintenance of tissue integrity.
 

It is well understood by all serious scientists that turnover, which links autophagy to niche construction is food energy-dependent and pheromone-controlled via the physiology of reproduction in bacteria. That fact has been linked from the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum of ecological, social, neurogenic, and socio-cognitive niche construction.

See: Olfaction Warps Visual Time Perception

The food energy-dependent pheromone-controlled physiology of reproduction is obviously the link between bacteria and healthy longevity and/or between bacteriophages, which link the virus-driven degradation of messenger RNA from  mutations to all pathology.

 Are stem cells the link between bacteria and cancer?

‘Our findings show that an infectious bacterium can increase stem cell turnover’, says Sigal. ‘Since H. pylori causes life-long infections, the constant increase in stem cell divisions may be enough to explain the increased risk of carcinogenesis observed,’ and Meyer adds: ‘Our new findings shed light on the intriguing ways through which chronic bacterial infections disturb tissue function and provide invaluable clues on how bacteria, in general, may increase the risk of cancer’.

Their findings show that the virus-driven degradation of messenger RNA in bacteria links the creation of virus-infected stem cells to cancer.

See also: 2nd International Congress on Contemporary Issues in Women Cancers & Gynecologic Oncology

This is a serious contemporary issue:

microRNA breast cancer

microRNA ovarian cancer

microRNA metastases

Two presentations from this conference series mention microRNAs:

CDE010 Title: Improving Breast Cancer diagnosis by circulating microRNAs

VP: MicroRNA-21 expression in primary breast cancer tissue among female patients and its correlation with chromosome 17 aneusomy

See also: Science Says: DNA test results may not change health habits

Getting the DNA information produced no significant effect on diet, physical activity, drinking alcohol, quitting smoking, sun protection or attendance at disease-screening programs.

That fits with other results showing that, on balance, getting the information “has little if any impact on changing routine or habitual behaviors,” said psychologist Theresa Marteau of Britain’s Cambridge University, a study author.

Under his leadership at the NIH, many people have been convinced that cancer is due to “bad luck.”

See:

Teaching people to believe in pseudoscientific nonsense (bad luck theory) ensures the success of the medical profession at the cost of the unnecessary suffering and death of your loved ones.

Healthy longevity is food energy-dependent and RNA-mediated. The virus-driven degradation of messenger RNA is linked to all pathology in all living genera.

DNA testing is largely irrelevant and most people will learn that in the context of the cell biology game “Cytosis,” where players compete to fight against viruses — as each of us must do in real life via food energy as information, which is the source for ATP and the de novo creation of RNA.

See also: Inhibiting a protein found to reduce progression of Alzheimer’s and ALS in mice

Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined.

The pathways are energy-dependent and the virus-driven theft of energy links changes in the microRNA/messenger RNA balance to all pathology. Proteins do not create themselves. That is why a PubMed search for microRNA and Alzheimer’s or for microRNA and ALS links everything known to serious scientists about biophysically constrained protein folding chemistry to healthy longevity or to the virus-driven degradation of messenger RNA, which links mutations to all pathology.

The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not create themselves.

See for comparison: Detecting ancient positive selection in humans using extended lineage sorting

Natural selection that affected modern humans early in their evolution has likely shaped some of the traits that set present-day humans apart from their closest extinct and living relatives.

Codon Optimality Is a Major Determinant of mRNA Stability

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

The amino acid optimality code links energy-dependent changes in chirality to autophagy and homeostasis unless the virus-driven degradation of messenger RNA prevents the optimization of the code by altering the microRNA/messenger RNA balance.

See also: pubmed – microRNA (https://www.ncbi.nlm.nih.gov/pubmed/?term=microRNA)
year count
2017 7158
2016 9983
2015 10495
2014 8776
2013 7450
2012 5853
2011 4405
2010 3440
2009 2277
2008 1562
2007 995
2006 651
2005 398
2004 213
2003 105
2002 36
2001 5
1972 1

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