See also: Energy as information and constrained endogenous RNA interference (2)

The Scope (Febrary 4, 2017)

On World Cancer Day, we’re featuring some of the most exciting research developments of the past year. First up? Yoshinori Ohsumi, Nobel laureate, whose research could save your life.

2016 Nobel Prize Winner Yoshinori Ohsumi’s Discoveries Could Change How We Treat Disease

His initial work, first started in 1992, focused on the genes behind the autophagy process in yeast cells. Autophagy, however, has implications for several human diseases, including cancer, neurodegenerative diseases, infectious diseases and diabetes.

Autophagy is the energy-dependent link from chirality to endogenous RNA interference in species from bacteria to humans. Examples of how virus-driven energy theft is linked to all pathology can be found when bacteria become archaea or in the context of the transgenerational epigenetic inheritance of Zika virus-damaged DNA in human infants.

The molecular mechanisms of nutrient energy-dependent feedback loops that link quorum sensing to protection of supercoiled DNA from entropy do not vary across species. They are biophysically constrained by the physiology of reproduction. All serious scientists know that. Only pseudoscientists and other theorists have been stuck touting neo-Darwinian theories.

See for comparison, my FB group: RNA-mediated  RNA-mediated currently has 815 members.


Light energy is quantized information. The information links physics, chemistry, and molecular epigenetics from…”

…the works of 2016 Nobel Laureate Ben Feringa to the works of 1933 Nobel Laureate Thomas Morgan Hunt, and the works of Schrodinger/Dirac who shared the 1933 Nobel Prize in Physics. Taken together, the refutation of neo-Darwinian nonsense about mutation-driven evolution has left theorists with no excuse.

Clearly, they should have examined the experimental evidence of biologically-based cause and effect sometime during the 20th century and stopped touting ridiculous theories based on their definitions and assumptions. If The Scope adds a report on the works of Ben Feringa, everyone could see that neo-Darwinian pseudoscientific nonsense has prevailed since 1933.  The facts have been ignored and/or replaced with alternative facts.

See for comparison: Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking

Reported as: Gamma oscillations coordinate food seeking

Gamma oscillations organize communication in hypothalamus

Optogenetics helped to shed light on neuronal mechanisms

Food seeking independent of food consumption

The section heads (above) confirm that energy as information must be linked from what organisms eat to their biophysically constrained physiology of  reproduction by the metabolism of food to pheromones. However, there is no mention of the fact that pheromones control the physiology of reproduction in species from bacteria to humans.

See: Feedback loops link odor and pheromone signaling with reproduction

Anyone who takes biologically-based cause and effect outside the context of the feedback loops has also failed to link chirality from autophagy to biodiversity in the context of species-specific survival via the chemistry of protein folding.

See: Multipurpose Plant Sensors Startle Scientists

Scientists at Pacific Northwest National Laboratory built a catalyst that mimics nature’s hydrogen-splitting enzymes—working reversibly at room temperature and pressure without added energy. This was achieved by stabilizing the catalyst’s structure by attaching an amino acid…

This means they could also link the sun’s anti-entropic virucidal energy from the speed of light on contact with water to chirality and autophagy, which link the physiology of reproduction from supercoiled DNA to all biodiversity via hydrogen atom transfer in DNA base pairs in solution and endogenous RNA interference.

See for comparison: Coevolutionary dynamics of phenotypic diversity and contingent cooperation

How to understand the emergence and persistence of cooperation is a key problem in evolutionary biology [1–12], since individuals sticking to cooperation produce benefits to others at a cost to themselves.

Reported as: Study finds mutual reinforcement of phenotypic diversity and cooperation

A new model exploring how evolutionary dynamics work in natural selection has found that phenotypic diversity, or an organism’s observable traits, co-evolves with contingent cooperation when organisms with like traits work together to protect themselves from outsiders, according to a Dartmouth-led study published in PLOS Computational Biology. The study also finds that diversity helps prevent the collapse of cooperation.

What is known about natural selection for energy-dependent codon optimality makes their claims about evolutionary dynamics as useless as James Shapiro’s claims about “Natural Genetic Engineering.” He links whatever that is to evolutionary time outside the context of anything known to serious scientists about energy-dependent biophysically constrained protein folding chemistry, which links endogenous RNA interference to supercoiled DNA.

See: How Living Organisms Make Genetic Edits

In this lecture presented by the American Society for Microbiology, you can learn about how and why modifications to genomes happen in living organisms. It was thought that genomic changes primarily occurred because of errors. But cells are able to adapt; they can make alterations to meet demands brought on by their conditions.

Nutrient energy-dependent amino acid substitutions in supercoiled DNA protect all organized genomes from virus-driven energy theft and genomic entropy. The title of Shapiro’s lecture is appropriate for those who want to think in terms of how life emerged and everything automagically evolved to change itself, but the amount of pseudoscientific nonsense he include in 38 minutes may be difficult to bear.

See also: Unraveling the Causes of Aging Using a Yeast Model

It is a report on a published work from March 2016. Mitochondria operate as signaling platforms in yeast aging

Rarely do we see science journalists and pseudoscientists like Jame Shapiro collaborate in attempts to keep touting the pseudoscientific nonsense of neo-Darwinian theories. The yeast model of RNA-mediated cell type differentiation was in clouded in our 1996 review and linked to biologically based cause and effect in other model organisms. See: From Fertilization to Adult Sexual Behavior. Ignoring the claims we made in our section on molecular epigenetics has become increasingly annoying.

For comparison, read What is Life? and watch What is life when it is not protected from virus-driven entropy.

See also: Fake news, which includes ridiculous posts like this from Matti Pitkanen Why metabolism and what happens in bio-catalysis?

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