…the Amish commitment to simple, productive lives and clean, local food is benefiting their health in ways that the rest of America can only dream about.
They exemplify what it means to be an ecologically adapted human population.
The facts support the beliefs of young earth creationists. That invites ridicule and denigration of my published works. But the experimental evidence of biologically-based cause and effect shows that 86.4% of the putatively deleterious protein-coding SNVs arose in the last 5,000 to 10,000 years.
See for comparison:
For comparison see: Critical values expose virus-driven energy theft
Autophagy cannot be discussed outside the context of how sunlight is linked from chirality to the de novo creation of G protein-coupled receptors and to all energy-dependent biodiversity, or from virus-driven energy theft to all pathology.
Measurement of pH in cord blood and measurement of bilirubin in neonates link the anti-entropic virucidal epigenetic effect of ultraviolet (UV) light to the treatment of infants who are in distress. Respiratory distress is linked from pH to the treatment and bilirubin is linked to the treatment with virucidal UV light.
Regulation of autophagy by amino acids.
Amino acid sensing and integration
Amino acid signalling is integrated by the RAG–Ragulator–v-ATPase complex on lysosomes to activate mTORC1 (REF. 98) (FIG. 4). Although consensus has not yet been reached, it is believed that the RAG heterodimer, composed of a RAS-related GTP-binding protein (RAG) A or RAGB monomer and a RAGC or RAGD monomer, contributes to mTORC1 activation98. mTORC1 is particularly sensitive to decreases in the levels of leucine, arginine and glutamine 88,99,100
Metabolic recycling of amino acids
The final stage of hepatic autophagy contributes to the amino acid supply through the breakdown of proteins. Hepatic autophagy is critical for maintaining systemic blood glucose levels during fasting by providing amino acids for the generation of glucose via hepatic gluconeogenesis
As autophagy has important roles in both quality control of organelles and the supply of amino acids and fatty acids to cancer cells, this degradation system is thought to support cancer survival and proliferation199. Selective autophagy enables the liver to efficiently and precisely control the quality and quantity of cytoplasmic organelles, including mitochondria, peroxisomes and lipid droplets, as well as the proper functioning of NRF2. Thus, selective autophagy is one strategy hepatocytes can utilize to adjust their cellular metabolic capacity. Conversely, inactivation of selective autophagy, which results in elevated oxidativestress and accumulation of SQSTM1-positive aggregates and lipid peroxides, is connected to chronic hepatitis virus infection, alcoholic steatohepatitis, NAFLD and HCC.
Metabolic adaptation through liver autophagy during fasting therefore proceeds via utilization of glycogen and fatty acids in the early phase and amino acids in the later phase.
See for comparison: Life is physics and chemistry and communication
Manfred Eigen extended Erwin Schroedinger’s concept of “life is physics and chemistry” through the introduction of information theory and cybernetic systems theory into “life is physics and chemistry and information.” Based on this assumption, Eigen developed the concepts of quasispecies and hypercycles, which have been dominant in molecular biology and virology ever since. He insisted that the genetic code is not just used metaphorically: it represents a real natural language. However, the basics of scientific knowledge changed dramatically within the second half of the 20th century. Unfortunately, Eigen ignored the results of the philosophy of science discourse on essential features of natural languages and codes: a natural language or code emerges from populations of living agents that communicate. This contribution will look at some of the highlights of this historical development and the results relevant for biological theories about life.
See also: The Strange Inevitability of Evolution
These ideas suggest that evolvability and openness to innovation are features not just of life but of information itself. That is a view long championed by Schuster’s sometime collaborator, Nobel laureate chemist Manfred Eigen, who insists that Darwinian evolution is not merely the organizing principle of biology but a “law of physics,” an inevitable result of how information is organized in complex systems. And if that’s right, it would seem that the appearance of life was not a fantastic fluke but almost a mathematical inevitability.
Healthy cells “communicate” to carry out processes in our body
Cells are called the building blocks of life because that’s precisely what they are: the smallest unit of life, with between 30 and 50 trillion of them making up the average human body. Within each tiny cell are components called organelles, including familiar names like the mitochondria and the nucleus, that work together, or communicate, to carry out all of the processes in our body. They convert food to energy, help our muscles contract when we walk, and secrete serotonin that gives us the sense of well-being.
Communication is essential to proper cell function
Cells function properly with consistent communication between organelles like the mitochondria and nucleus, which are dependent on each other. Healthy communication leads to optimal performance in hundreds of functions. One of the most important communication-dependent processes is mitochondrial function, since the mitochondria turn nutrition into energy. Proper communication is the key to having sufficient energy to carry out all of the cells’ functions.
Basis is a proprietary formulation of two compounds — nicotinamide riboside (a unique form of vitamin B3) and pterostilbene (a powerful antioxidant) — in capsule form. It’s designed to support healthy levels of NAD+, which is essential to fundamental cellular function in over 500 areas, including creating energy and maintaining the integrity of our DNA.
Why Don’t The Amish Get Cancer? (revisited)
They are ecologically adapted. That’s why. Most people are not ecologically adapted. That’s why they suffer and die from virus-driven energy theft, which causes all pathology.