TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

… we report the existence of a TRIM28-controlled gene regulatory network based on ERVs that is active in hNPCs. Our findings open up for several exciting future studies on the role of ERVs as potential drivers of human brain evolution, their contribution to individual variation, and the implication in human brain disorders.

All gene regulatory networks are energy-dependent. They must link the sun’s anti-entropic virucidal energy to chirality. They must link chirality from hydrogen-atom transfer in DNA base pairs in solution to RNA-mediated amino acid substitutions in supercoiled DNA. They must link the supercoiled DNA to all morphological and behavioral diversity via biophysically constrained protein folding chemistry, which prevents virus-driven energy theft from organized genomes.

Organized genomes link chromosomal inheritance to all biodiversity. The idea that a the co-repressor protein such as TRIM28 controls its own gene regulatory network and the evolution of the brain is simple-minded and absurd.

No consideration is given for how virus-driven energy theft links mutations to all pathology. Chirality is reality and energy-dependent viral latency links human endogenous retroviruses from ecological variation to ecological adaptation.

Ecological adaptation is manifested in energy-dependent chromosomal rearrangements and all biodiversity, which links the physiology of reproduction to transgenerational epigenetic inheritance of healthy longevity until stress-linked activation of endogenous retroviruses overcomes the innate immune system of the host. Natural selection for energy-dependent codon optimality is the only protection that enables ecological variation to be linked to ecological adaptation throughout life, and eventually the viruses cause death. Preventative measures are invariably temporary, but they do not link prevention of virus-driven energy theft to any ridiculous theories about evolution.

See for contrast: Epigenome: The symphony in your cells

A large international group of researchers has put together 111 epigenomes from different human cell types, including all the major organs, immune cells and embryonic stem cells

Video from “Nature about the music of life placed into the context of communication among cells.

For comparison at the macroscopic level of examination, see: Jim Kohl at the Legacy Hall Jam 1/3/2017 and return to the more technical links from physics and chemistry to molecular epigenetics if you feel the need to know more about the music of life than what evolutionary theorists will tell you.

For example, friends from last night’s jam session helped me to correct my modified arrangement of “Teach Your Children” so that others could play it, and so that they could add the harmony.

Next time, they will not be subjected to my hecatombic massacre of the original arrangement. I substituted one chord for ~ 1/10th of the guitar chords used in the original version. The result was akin to what happens to bacteria when virus-driven energy theft causes the degradation of messenger RNA and the bacteria become archaea. See: Virus-mediated archaeal hecatomb in the deep seafloor

In my transposition to the key of A, I couldn’t find the best fit for the F#m. By decreasing the vibrational frequency to the key of G, the F#m becomes an Em followed by a D, C and another D. I added 4 chords back to the 42 chord arrangement, which reminded me of how the hecatombic evolution of pathology alters the music of life.

That’s why I decided to put the energy-dependent transposition from G to A into the context of nutrient energy-dependent codon optimality and autophagy, which is the missing link to Denis Noble’s “Music of Life.” Only after my friends helped me to recognize that the vibrational frequency change from the key of G to the key of A was not  a sudden jump, did I go back to find what was missing from my arrangement of the chords.

Denis Noble and his cronies will continue to ignore fact about how autophagy fine-tunes the frequencies that ensure the music of life is played and they will tout theories instead of rearranging their thought processes and world view to include what virus-driven energy theft does to Darwin’s “conditions of life” or to the “music of life.”

For comparison, the virus-driven theft of energy links changes in gamma oscillations (20-50 Hz) to several neurological disorders.

See: Gamma frequency entrainment attenuates amyloid load and modifies microglia

One of the disorders is manifested as an inability to appreciate music. Lack of joy from music linked to brain disconnection.

Other virus-driven pathology is more important to the quality of life. But it is a waste of time and energy to explain gamma frequency entrainment or anything else to a theorist. They refuse to learn about how physics and chemistry must be linked from ecological variation to ecological adaptation.

Theorists seem to think that the music of life was arranged via a series of beneficial mutations that were naturally selected. Natural selection automagically led to the evolution of birds from dinosaurs and to the evolution of modern humans from non-human primates. Simply put, theorists believe in pseudoscientific nonsense.

 

 

 

Leave a comment

Your email address will not be published. Required fields are marked *

error: Content is protected !!