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What's in the News

Ok… But What is Autophagy?


Recent Articles

Quantized energy-dependent microRNA-mediated autophagy (2) Quantized energy-dependent microRNA-mediated autophagy (2)

Summary: A single genetic change provided complete protection against an invariably lethal dementia. A naturally occurring variant of the human prion protein completely prevents prion disease (2015) …mice expressing only PrP V127 were completely resistant to all prion strains, demonstrating a different molecular mechanism to M129V, which provides its relative protection against classical CJD and […]

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Quantized energy-dependent microRNA-mediated autophagy Quantized energy-dependent microRNA-mediated autophagy

How to stop virus-driven activation of your death genes. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (2011) See: Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death (2018) Reported as:  Is it possible to kill cancer […]

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Quantized energy-dependent mTORC1 and autophagy Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid […]

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Estranged ‘White Coat Notes’ blogger exposes human idiocy (2) Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

Conclusion: …there are constraints on the mixed state entanglement… The biophysical constraints attest to the fact that quantum entanglement in photosynthetic complexes does not evolve. The works of two people who recently became members of the RNA-mediated FaceBook group attest to the overwhelming ignorance of biologically uninformed theorists. See for example: The C. elegans hunchback […]

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Estranged ‘White Coat Notes’ blogger exposes human idiocy (1) Estranged ‘White Coat Notes’ blogger exposes human idiocy (1)

Excerpt: Please pardon the overwhelming ignorance of those who failed to link what organisms eat from the quantized energy-dependent creation of microRNAs to healthy longevity via the pheromone-controlled physiology of reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from microbes to humans. The ignorance of biologically uninformed theorists has […]

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Darwinian adaptation: a clear evolutionary trail? Darwinian adaptation: a clear evolutionary trail?

Summary: The light harvesting occurs in the ocean and on land. It links the creation of sunlight from food energy to the physiology of pheromone-controlled viral latency in all living genera, and all serious scientists know that.   Origins of photosynthesis in plants dated to 1.25 billion years ago The world’s oldest algae fossils are […]

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The tipping point (revisited): 68,000 publications The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17) See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17 The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical […]

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Agilent technology and energy-dependent autophagy Agilent technology and energy-dependent autophagy

The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the  technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked  to the prevention of the virus-driven degradation of messenger RNA […]

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